Regulation of Cardiovascular Signaling by Kinins and Products of Similar Converting Enzyme Systems Changes in amino-terminal portion of human B2 receptor selectively increase efficacy of synthetic ligand HOE 140 but not of cognate ligand bradykinin
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چکیده
Christian Schroeder,1 Andreas Breit,2,5 Hilke Böning,3,5 Jürgen Dedio,2,4 Lajos Gera,6 John Stewart,6 and Werner Müller-Esterl2 1Institute for Cardiovascular and Arteriosclerosis Research, Bayer D-42096, Wuppertal; 2Institute for Biochemistry II, The University of Frankfurt Medical School, D-60590 Frankfurt; 3Department of Biochemistry, University of Münster, D-48419 Münster; 4Aventis, Disease Group Research Frankfurt, 65926 Frankfurt, Germany; 5Department of Biochemistry, University of Montreál, Montreál H3C 3J7, Canada; and 6Department of Biochemistry, University of Colorado Medical School, Denver, Colorado 80262
منابع مشابه
Regulation of Cardiovascular Signaling by Kinins and Products of Similar Converting Enzyme Systems Kininase I-type carboxypeptidases enhance nitric oxide production in endothelial cells by generating bradykinin B1 receptor agonists
Sangsree, Sakonwun, Viktor Brovkovych, Richard D. Minshall, and Randal A. Skidgel. Kininase I-type carboxypeptidases enhance nitric oxide production in endothelial cells by generating bradykinin B1 receptor agonists. Am J Physiol Heart Circ Physiol 284: H1959–H1968, 2003. First published March 6, 2003; 10.1152/ajpheart.00036.2003. Kininase I-type carboxypeptidases convert native kinin agonists ...
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The contribution of endogenous kinins to the chronic antihypertensive effect of angiotensin converting enzyme inhibitors was investigated in two-kidney, one clip hypertensive Wistar rats, using the new bradykinin B2-receptor antagonist HOE 140 (D-Arg, [Hyp3, Thi5, D-Tic7, Oic8]-bradykinin). In a first protocol, rats were pretreated orally with the angiotensin converting enzyme inhibitor ramipri...
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ABSTRACT Most of physiological effects of bradykinin is due to its effect on bradykinin B2 receptors. There is no reports of preparation of a photoactivatable analogue of bradykinin reactive with sloubilized bradykinin B2 recpetors. Photoactivatable radioactive ligands are powerful tools in purification of receptors. In this study we report preparation of a photoactivatable iodinatable analo...
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Joost P. Schanstra,1 Johan Duchene,1 Françoise Praddaude,1 Patrick Bruneval,2 Ivan Tack,1 Jacques Chevalier,2 Jean-Pierre Girolami,1 and Jean-Loup Bascands1 1Institut National de la Santé et de la Recherche Médicale U388, Institut Louis Bugnard, Centre Hospitalier Universitaire Rangueil, 31052 Toulouse; 2Institut National de la Santé et de la Recherche Médicale U430, Hôpital Broussais, 75674 Pa...
متن کاملAcute ACE inhibition causes plasma extravasation in mice that is mediated by bradykinin and substance P.
The use of angiotensin-converting enzyme (ACE) has been associated with the occurrence of adverse effects, including cough and angioneurotic edema. Accumulation of kinins has been suggested to play a major role in these adverse effects of ACE inhibitor, although conclusive evidence for such a role is lacking. We investigated whether ACE inhibition increases plasma extravasation in mice (Swiss, ...
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تاریخ انتشار 2003